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Dr Sankari Nagarajan

Dr Sankari Nagarajan.
Molecular biologist with 8 years of research experience studying the epigenetic and transcriptional mechanisms in breast cancers.

Lecturer in Chromatin Biology

C.2260 Michael Smith Building
Oxford Road
The University of Manchester
M13 9PT



  • Senior Research Associate, Cancer Research UK Cambridge Institute, 11 Dec 2019 - 30 Jun 2020
  • Research Associate, Cancer Research UK Cambridge Institute, 2 Nov 2015 - 11 Dec 2019
  • Postdoctoral fellow, Georg-August-Universitat Gottingen, 1 Apr 2015 - 31 Oct 2015

Education / academic qualifications

  • 2015 - Doctor of Philosophy, Role of BRD4 and histone acetylation in estrogen receptor positive breast cancers, Georg-August-Universitat Gottingen (2011 - 2015)
  • 2010 - Master in Science, Bio-Medical Science, Bharathidasan University (2005 - 2010)

Breast cancer bone metastases are attenuated in a Tgif1-deficient bone microenvironment

Haider, M., Saito, H., Zarrer, J., Uzhunnumpuram, K., Nagarajan, S., Kari, V., Horn-glander, M., Werner, S., Hesse, E. & Taipaleenmäki, H., 1 Dec 2020, In: Breast Cancer Research. 22, 1

Research output: Contribution to journal › Article › peer-review

DOI: 10.1186/s13058-020-01269-8 

IL6/STAT3 Signaling Hijacks Estrogen Receptor a Enhancers to Drive Breast Cancer Metastasis

Nagarajan, S., 14 Sep 2020, In: Cancer Cell. 38, 3

Research output: Contribution to journal › Article › peer-review

DOI: 10.1016/j.ccell.2020.06.007

ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

Nagarajan, S., Rao, S. V., Sutton, J., Cheeseman, D., Dunn, S., Papachristou, E. K., Prada, J. G., Couturier, D., Kumar, S., Kishore, K., Chilamakuri, C. S. R., Glont, S., Archer Goode, E., Brodie, C., Guppy, N., Natrajan, R., Bruna, A., Caldas, C., Russell, A., Siersbæk, R. & 3 others, , 1 Feb 2020, In: Nature Genetics. 52, 2, p. 187-197

Research output: Contribution to journal › Article › peer-review

DOI: 10.1038/s41588-019-0541-5

VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer

Holding, A. N., Giorgi, F. M., Donnelly, A., Cullen, A. E., Nagarajan, S., Selth, L. A. & Markowetz, F., 1 Dec 2019, In: Genome biology. 20, 1

Research output: Contribution to journal › Article › peer-review

DOI: 10.1186/s13059-019-1698-z 

A context-specific cardiac ß-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart

Iyer, L. M., Nagarajan, S., Woelfer, M., Schoger, E., Khadjeh, S., Zafiriou, M. P., Kari, V., Herting, J., Pang, S. T., Weber, T., Rathjens, F. S., Fischer, T. H., Toischer, K., Hasenfuss, G., Noack, C., Johnsen, S. A. & Zelarayán, L. C., 6 Apr 2018, In: Nucleic acids research. 46, 6, p. 2850-2867

Research output: Contribution to journal › Article › peer-review

DOI: 10.1093/nar/gky049 

Nagarajan lab is interested in unravelling the mechanisms of enhancer regulation and the role of transcription factors in mediating the progression to drug resistance and metastasis in aggressive cancers. We utilise single cell analyses, functional genomic technologies, quantitative chromatin-based proteomics and CRISPR-Cas9 assays to decipher the mechanisms of transcription.

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3

Jozwik, K. M., Chernukhin, I., Serandour, A. A., Nagarajan, S. & Carroll, J. S., 1 Dec 2016, In: Cell Reports. 17, 10, p. 2715-2723

Research output: Contribution to journal › Article › peer-review

DOI: 10.1016/j.celrep.2016.11.028 


H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription

Nagarajan, S., Benito, E., Fischer, A. & Johnsen, S. A., 30 Mar 2015, In: Oncotarget. 6, 9, p. 7305-7317

Research output: Contribution to journal › Article › peer-review

DOI: 10.18632/oncotarget.v6i9 


Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription

Nagarajan, S., Hossan, T., Alawi, M., Najafova, Z., Indenbirken, D., Bedi, U., Taipaleenmäki, H., Ben-batalla, I., Scheller, M., Loges, S., Knapp, S., Hesse, E., Chiang, C., Grundhoff, A. & Johnsen, S., 1 Jul 2014, In: Cell Reports. 8, 2, p. 460-469

Research output: Contribution to journal › Article › peer-review

DOI: 10.1016/j.celrep.2014.06.016