Selected Publications from 2021


Time-resolved single-cell analysis of Brca1 associated mammary tumorigenesis reveals aberrant differentiation of luminal progenitors
Bach K, Pensa S, Zarocsinceva M, Kania K, Stockis J, Pinaud S, Lazarus KA, Shehata M, Greenhalgh AR, Simões BM, Howell SJ, Clarke RB, Caldas C, Halim TYF, Marioni JC and Khaled WT
Nature Communications  2021  12(1):1502. 
Patient and public priorities for breast cancer research: a qualitative study in the UK
Boundouki G, Wilson R, Duxbury P, Henderson J, Balance L, Wray J, Appanah V,3 Ibrahim I, Harvey J, Kirwan CC, on behalf of the Northwest Breast Research
BMJ Open   2021  Jan 29;11(1):e036072 
Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women
Breast Cancer Association Consortium, Dorling L et al., (Evans DG, Howell A)
N Engl J Med  2021  Jan 20. doi: 10.1056/NEJMoa1913948 
Do surgical margins matter after mastectomy?
Bundred J, Michael S, Bowers S, Barnes N, Jauhari Y, Plant D, Maishman T, Cutress R, Holleczek B, Dodwell D, Bundred N
Eur J Surg Oncol  2020  Dec;46(12):2185-2194. doi: 10.1016/j.ejso.2020.08.015. Epub 2020 Aug 2 
Residual lymph node tumour burden following removal of a single axillary sentinel lymph node with macrometastatic disease in women with screen detected invasive breast cancer
Dave RV, Cheung S, Sibbering M, Kearins O, Jenkins J, Gandhi A
Br J Surgery Open  2021  5(2)  
Breast Cancer Management Pathways during the COVID-19 pandemic. Outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study
Dave RV, Kim B, Courtney A, O’Connell R, Rattay T, Taxiarchi VP, Kirkham JJ, Camacho EM, Fairbrother P, Sharma N, Cartlidge C.W.J., Horgan K, McIntosh SA, Leff DR, Vidya R, Potter S, Holcombe C, Copson E, Coles CE, Cutress RI, Gandhi A, Kirwan CC
British Journal of Cancer  2021  May;124(11):1785-1794 
Randomised controlled trial of intermittent versus continuous energy restriction during chemotherapy for early breast cancer
Harvie M, Pegington M, Howell SJ, Bundred N, Foden P, Adams J, Graves L, Greystoke A, Mattson MP, Cutler RG, Williamson J, Livingstone K, McMullen D, Sellers K, Lombardelli C, Cooper G, McDiarmid S, Howell A
Br J Cancer   2021  Dec 15. doi: 10.1038/s41416-021-01650-0. Online ahead of print. 
Peptide location fingerprinting reveals modification-associated biomarker candidates of ageing in human tissue proteomes
Ozols M, Eckersley A, Mellody KT, Mallikarjun V, Warwood S, O’Cualain R, Knight D, Watson REB, Griffiths CEM, Swift J, Sherratt MJ
Aging Cell   2021  May;20(5):e13355. doi: 10.1111/acel.13355. Epub 2021 Apr 8. 
A new framework for developing and evaluating complex interventions: Update of Medical Research Council guidance
Skivington K, Matthews L, Simpson SA, Craig P, Baird J, Blazeby JM, Boyd KA, Craig N, French DP, McIntosh E, Petticrew M, Rycroft-Malone J, White M, Moore L
British Medical Journal   2021  374; n2061 
Long-term outcome and prognostic value of Ki67 after perioperative endocrine therapy in postmenopausal women with hormone-sensitive early breast cancer (POETIC): an open-label, multicentre, parallel-group, randomised, phase 3 trial
Smith I, Robertson J, Kilburn L, Wilcox M, Evans A, Holcombe C, Horgan K, Kirwan C, Mallon E, Sibbering M, Skene A, Vidya R, Cheang M, Banerji J, Morden J, Sidhu K, Dodson A, Bliss JM, Dowsett M
Lancet Oncol.   2020  Nov;21(11):1443-1454 
Elevated EDAR signalling promotes mammary gland tumourigenesis with squamous metaplasia
Williams R, Jobling S, Sims AH, Mou C, Wilkinson L, Collu GM, Streuli CH, Gilmore AP, Headon DJ, Brennan K
Oncogene  2021  Dec 16. doi: 10.1038/s41388-021-01902-6. Online ahead of print. PMID: 34916592 
BROWSE: A multicentre comparison of nine year outcomes in acellular dermal matrix based and complete submuscular implant-based immediate breast reconstruction-aesthetics, capsular contracture and patient reported outcomes
Wilson RL, Kirwan CC, O'Donoghue JM, Linforth RA, Johnson RK, Harvey JR
Eur J Surg Oncol.  2021  Nov 6:S0748-7983(21)00776-9. doi: 10.1016/j.ejso.2021.10.026. Epub ahead of print. PMID: 34836730. 
Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts
Woo et al., PDXNET consortium & EurOPDX consortium (Clarke RB)
Nature Genetics  2021  53(1):86-99 
Clinical utility of testing for PALB2 and CHEK2 c.1100delC in breast and ovarian cancer
Woodward ER, van Veen EM, Forde C, Harkness EF, Byers HJ, Ellingford JM, Burghel GJ, Schlech H, Bowers NL, Wallace AJ, Howell SJ, Howell A, Lalloo F, Newman WG, Smith MJ, Gareth Evans D
Genet Med  2021  Jun 10. doi: 10.1038/s41436-021-01234-6  
The extracellular-regulated protein kinase 5 (ERK5) enhances metastatic burden in triple-negative breast cancer through focal adhesion protein kinase (FAK)-mediated regulation of cell adhesion
Xu Q, Zhang J, Telfer B, Zhang H, Ali N, Chen F, Risa B, Pearson AJ, Zhang W, Finegan KG, Ucar A, Giurisato E, Tournier C
Oncogene  2021  40, 3929-3941.  


Date:  24 May 202415:00
Speaker:  Dr Gerald Lip
From:  NHS Grampian & University of Aberdeen
Title:  AI in breast cancer screening - are we there yet?
Host:  Sue Astley
Date:  18 July 202400:00
Speaker:  Andrea Morandi
From:  University of Florence, Italy
Title:  TBC
Host:  Rob Clarke
Date:  18 July 202400:00
Speaker:  Ernestina De Francesco
From:  Universities of Catania and Enna, Italy
Title:  TBC
Host:  Rob Clarke