Principal Investigators

Andrew Gilmore

Andrew Gilmore

Senior Lecturer

Andrew's lab is interested in how adhesion mediated signalling regulates mammary epithelial cell survival.

University of Manchester Research Profile

Email: andrew.gilmore@manchester.ac.uk

Anne Armstrong

Anne Armstrong

Senior Lecturer

Anne carries out clinical studies of new treatments in breast cancer and leads trials of investigational agents in triple negative disease.

The Christie Consultant Profile

Email: anne.armstrong3@nhs.net

Ashu Gandhi

Ashu Gandhi

Consultant Oncoplastic Breast & Endocrine Surgeon

Ashu has a range of research interests such the surgical treatment of women genetically predisposed to breast cancer, collaborations with colleagues in the basic sciences and the improvement of breast cancer care in ethnic minority women.

Ciara O'Brien

Ciara O'Brien

Consultant and Honorary Senior Lecturer in Medical Oncology

Ciara runs academic and commercial clinical trials in breast cancer alongside collaborative translational research projects focusing on molecular drivers and biomarkers of the metastatic niche in breast cancer.

The Christie Consultant Profile

Cliona Kirwan

Cliona Kirwan

Professor of Surgical Trials and Consultant Oncoplastic Breast Surgeon

Cliona develops and delivers clinical trials as well as conducting translational research focussing on the symbiotic relationship between cancer and clotting

University of Manchester Research Profile

Email: Cliona.Kirwan@manchester.ac.uk

David French

David French

Professor of Health Psychology

David's research has focussed on understanding how patients experience changes in screening/ early detection services (e.g. risk stratified screening) and how best to design these services, taking into account the views of patients and clinicians.

University of Manchester Research Profile

Email: david.french@manchester.ac.uk

Emma Woodward

Emma Woodward

Consultant Clinical Geneticist and Honorary Senior Lecturer

Emma's current research is aimed at understanding the inherited predisposition to cancer, and also whether structural genomic variants influence cancer predisposition risk.

Email: Emma.Woodward@mft.nhs.uk

Emma Woodward

Frances Turrell

Lecturer in Cancer Biology

Frances’ research interests centre on ER+ breast cancer metastasis.

Email: Frances.Turrell@manchester.ac.uk

Gareth Evans

Gareth Evans

Professor of Medical Genetics and Cancer Epidemiology, Cancer Lead for the Manchester Biomedical Research Centre, Consultant in Medical Genetics and Cancer Epidemiology

Gareth's research has focused on genetic predisposition to breast cancer.

University of Manchester Research Profile

Email: Gareth.Evans@mft.nhs.uk

James Harvey

James Harvey

Consultant Oncoplastic Breast Surgeon

James' research interests are: - Breast device studies; including localisation devices, reconstructive mesh, post marketing surveillance studies. - Research into breast reconstruction and outcomes.

Manchester University NHS Foundation Trust Consultant Profile

Email: james.harvey@mft.nhs.uk

Keith Brennan

Keith Brennan

Professor of Developmental Signalling and Vice Dean for Internationalisation

Keith's lab research focuses on the role developmental signalling pathways play in the initiation of cancer - particularly the role of Notch signalling in breast cancer.

University of Manchester Research Profile

Email: Keith.Brennan@manchester.ac.uk

Michael Sherratt

Michael Sherratt

Professor of Biochemistry

Mike's lab uses a range of biophysical and biochemical techniques to characterise the composition, structure and mechanical properties of tissues. Changes in these properties are associated with ageing, disease and aberrant cell behaviour.

University of Manchester Research Profile

Email: michael.j.sherratt@manchester.ac.uk

Michelle Harvie

Michelle Harvie

Research Dietician

Michelle's research looks at how we can prevent breast cancer and its recurrence through diet, weight control and physical activity.

Email: Michelle.Harvie@manchester.ac.uk

Rajiv Dave

Rajiv Dave

Consultant Oncoplastic Breast and Endocrine Surgeon

Rajiv has both clinical and translational research interests. His main area of research expertise lies in ‘Real World’ data through collaborative national/international research, including the management of breast cancer during the COVID-19 pandemic.

Email: rajiv.dave@nhs.net

Robert Clarke

Robert Clarke

Professor of Breast Biology & Director of the Manchester Breast Centre

Rob's lab investigates the signalling pathways that differentially regulate stem cell self-renewal in normal versus cancer stem cells. An additional research area is the discovery of novel markers that can be used to isolate and purify these stem cell populations.

University of Manchester Research Profile

Email: robert.clarke@manchester.ac.uk

Sacha Howell

Sacha Howell

Senior Lecturer and Honorary Consultant in Medical Oncology

Sacha's research interests are in translational breast oncology with the main focus on breast cancer prevention.

University of Manchester Research Profile

Email: sacha.howell@nhs.net

Sankari Nagarajan

Sankari Nagarajan

Lecturer in Chromatin Biology, CRUK Career Establishment Award holder

The Nagarajan research lab is interested in unravelling the mechanisms of enhancer regulation and the role of transcription factors in mediating the progression to drug resistance and metastasis in aggressive cancers.

University of Manchester Research Profile,   Nagarajan Lab Website

Email: sankari.nagarajan@manchester.ac.uk

Sue Astley

Sue Astley

Professor of Medical Imaging

Sue's research includes evaluation of novel imaging technologies (CAD, DBT), developing software to detect abnormalities and discover imaging biomarkers, using eye tracking to learn how new imaging systems are best employed and working with radiologists to achieve clinically useful solutions.

University of Manchester Research Profile  

Email: sue.astley@manchester.ac.uk

 

Emeritus Principal Investigators

Charles Streuli

Charles Streuli

Emeritus Professor of Cell Biology, Former Director of the Wellcome Trust Centre for Cell-Matrix Research & Joint founder of the Manchester Breast Centre

Charles' former research lab was focussed on how cell-matrix interactions are involved with lactation and mammary gland function, and on how altered cell-matrix interactions contribute to the onset of breast cancer.

University of Manchester Research Profile  

Email: c.streuli@mac.com

Nigel Bundred

Nigel Bundred

Professor of Surgical Oncology & Joint founder of the Manchester Breast Centre

Nigel's research areas encompass breast cancer prevention, mechanisms of bone metastasis, angiogenesis, stem cell (non-adherent) culture of DCIS and invasive breast cancer. Other areas of interest include endocrine therapy of breast cancer and tumour tissue analysis (microarray).

University of Manchester Research Profile  

Email: nigel.bundred@manchester.ac.uk

Tony Howell

Tony Howell

Emeritus Professor of Medical Oncology, Co-Director, Prevent Breast Cancer Unit, Nightingale Breast Screening Centre & Joint founder of the Manchester Breast Centre

Tony Howell's contribution to medical science is in laboratory and clinical studies on the breast and in clinical science administration.

University of Manchester Research Profile  

Email: anthony.howell@manchester.ac.uk