Milestones

Manchester has long played a key role in the development of new approaches for the prevention, diagnosis and treatment of breast cancer. Explore our world-leading discoveries here.

Edith Paterson
1944

Targeted therapies in breast cancer: stil-boestrol and phenylethylene (early tamoxifen like inhibitor)

Ralston Paterson
1948

First randomised trial in cancer: adjuvant ovarian irradiation

Moya Cole and Ian Todd
1969

First clinical use of tamoxifen

Andrew Baildam and Tony Howell
1987

First pre-surgical use of tamoxifen

Charles Streuli
1991

Control of mammary differentiation by extra cellular matrix

Rob Clarke
1997

ER+ cells rarely divide in mammary epithelium

Nigel Bundred
1999

Xeno-transplantation model of human DCIS

Rob Clarke
2005

Identification and regulation of stem cells in human breast epithelium

Keith Brennan
2006

Aberrant activation of Notch in Breast Cancer

Gillian Farnie
2007

Identification of stem cells in ductal carcinoma in situ

Gareth Evans
2007

Identification of novel breast cancer susceptibility genes

Sacha Howell
2008

A role for prolactin in breast cancer stem cells

Andrew Gilmore
2009

Focal Adhesion Kinase (FAK) regulates apoptosis in mammary epithelial cells

Michelle Harvie
2013

The 5:2 (intermittent) diet for breast cancer reduction in high risk women