Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis.
Eyre, R., Alférez, D. G., Spence, K., Kamal, M., Shaw, F. L., Simões, B. M., Santiago-Gómez, A., Sarmiento-Castro, A., Bramley, M., Absar, M., Saad, Z., Chatterjee, S., Kirwan, C., Gandhi, A., Armstrong, A. C., Wardley, A. M., O'Brien, C. S., Farnie, G., Howell, S. J. & Clarke, R. B.
Journal of Mammary Gland Biology and Neoplasia. 28 Sep 2016.
Low prevalence of HER2 positivity amongst BRCA1 and BRCA2 mutation carriers and in primary BRCA screens
Evans, G., Lalloo, F., Howell, S., Verhoef, S., Woodward, E. R. & Howell, A. 18 Feb 2016
Breast Cancer Research and Treatment. 2016. 155(3):597-601
A phase II trial of low-dose estradiol in postmenopausal women with advanced breast cancer and acquired resistance to aromatase inhibition
Zucchini, G., Armstrong, A. C., Palmieri, C., Howell, S. J., Wardley, A. M., Wilson, G., Misra, V., Seif, M., Ryder, W. D., Cope, J., Blowers, E. & Howell, A.
European Journal of Cancer. 2015. 51(18):2725-31
Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.
Simões, B. M., O'Brien, C. S., Eyre, R., Silva, A., Yu, L., Sarmiento-Castro, A., Alférez, D. G., Spence, K., Santiago-Gómez, A., Chemi, F., Acar, A., Gandhi, A., Howell, A., Brennan, K., Rydén, L., Catalano, S., Andó, S., Gee, J., Ucar, A., Sims, A. H., Marangoni, E., Farnie, G., Landberg, G., Howell, S. J., Clarke, R. B.
Cell Reports. 2015. 12, 12, p. 1968-1977 9 p.
The role of steroid hormones in breast cancer stem cells
Simões, B. M., Alferez, D., Howell, S. & Clarke, R. 17 Sep 2015
Endocrine-related cancer. 2015. 22(6):T177-86
Neoadjuvant chemotherapy and trastuzumab versus neoadjuvant chemotherapy followed by post-operative trastuzumab for patients with HER2-positive breast cancer.
Palmieri, C., Macpherson, I. R., Yan, K., Ades, F., Riddle, P., Ahmed, R., Owadally, W., Stanley, B., Shah, D., Gojis, O., Januszewski, A., Lewanski, C., Asher, R., Lythgoe, D., de Azambuja, E., Beresford, M. & Howell, S. J.
Oncotarget. 2015. 15;7(11):13209-20.
Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy.
Lamb, R., Fiorillo, M., Chadwick, A., Ozsvari, B., Reeves, K. J., Smith, D., Clarke, R., Howell, S. J., Cappello, A. R., Martinez-Outschoorn, U. E., Peiris Pages, M., Sotgia, F. & Lisanti, M.
Oncotarget. 2015. 6(16):14005-25.
Breast cancer: current and future endocrine therapies.
Palmieri C, Patten DK, Januszewski A, Zucchini G, Howell SJ.
Mol Cell Endocrinol. 2014 Jan 25;382(1):695-723. doi: 10.1016/j.mce.2013.08.001.
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.
Eccles SA et al.
Breast Cancer Res. 2013 Oct 1;15(5):R92. doi: 10.1186/bcr3493.
Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms.
Singh JK, Farnie G, Bundred NJ, Simões BM, Shergill A, Landberg G, Howell SJ, Clarke RB.
Clin Cancer Res. 2013 Feb 1;19(3):643-56. doi: 10.1158/1078-0432.CCR-12-1063.
HER2-targeted therapy in breast cancer: a systematic review of neoadjuvant trials.
Dent S, Oyan B, Honig A, Mano M, Howell S.
Cancer Treat Rev. 2013 Oct;39(6):622-31. doi: 10.1016/j.ctrv.2013.01.002.
The clinical effectiveness and cost-effectiveness of genotyping for CYP2D6 for the management of women with breast cancer treated with tamoxifen: a systematic review.
Fleeman N, Martin Saborido C, Payne K, Boland A, Dickson R, Dundar Y, Fernández Santander A, Howell S, Newman W, Oyee J, Walley T.
Health Technol Assess. 2011 Sep;15(33):1-102. doi: 10.3310/hta15330.
Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer.
Board RE, Wardley AM, Dixon JM, Armstrong AC, Howell S, Renshaw L, Donald E, Greystoke A, Ranson M, Hughes A, Dive C.
Breast Cancer Res Treat. 2010 Apr;120(2):461-7. doi: 10.1007/s10549-010-0747-9.
Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.
Harrison H, Farnie G, Howell SJ, Rock RE, Stylianou S, Brennan KR, Bundred NJ, Clarke RB.
Cancer Res. 2010 Jan 15;70(2):709-18. doi: 10.1158/0008-5472.CAN-09-1681.