2022 publications:
RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells
Chen F, Gurler SB, Novo D, Selli C, Alferez D, Eroglu S, Pavlou K, Zhang J, Sims AH, Humphreys N, Adamson A, Campbell A, Sansom OJ, Tournier C, Clarke RB, Brennan K, Streuli C and Ucar A (2022) , Oncogene, in press.
The Prevention of Breast and Endometrial cancer using Total Diet Replacement (PROBE-TDR) Trial; Protocol for a Randomised Controlled Trial
Clarke, H., Harvie, M., Lombardelli, C., Krizak, S., Sellers, K., Harrison, H., Lim, Y. Y., Parkin, C., Patel, S., Issa, B., Maxwell, A., Wisley, J., Belcher, J., Clarke, R., Howell, T., Crosbie, E. & Howell, S. (2022) , BMJ Open, 12, 7, e057161.
High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer
Palafox M, Monserrat L, Bellet M, Villacampa G, Gonzalez-Perez A, Oliveira M, Brasó-Maristany F, Ibrahimi N, Kannan S, Mina L, Herrera-Abreu MT, Ódena A, Sánchez-Guixé M, Capelán M, Azaro A, Bruna A, Rodríguez O, Guzmán M, Grueso J, Viaplana C, Hernández J, Su F, Lin K, Clarke RB, Caldas C, Arribas J, Michiels S, García-Sanz A, Turner NC, Prat A, Nuciforo P, Dienstmann R, Verma C, Lopez-Bigas N, Scaltriti M, Arnedos M, Saura C, Violeta Serra V (2022) . Nature Communications, 13, (1), 5258-5277.
Targeting progesterone reduces epigenetic and genetic cancer surrogates in normal breast tissue
Bartlett TE, Evans I, Jones A, Barrett JE, Haran S, Reisel D, Papaikonomou K, Jones L, Simões BM, Clarke RB, Evans DG, Ghezelayagh TS, Ponandai-Srinivasan, Boggavarapu SNR, Lalitkumar PG, Howell SJ, Risques RA, Rådestad AF, Dubeau L, Gemzell-Danielsson K and Widschwendter M*. (2022) , Genome Medicine, 14 (1), 1-18.
Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification
Pellegrino B, Herencia A, Llop-Guevara A, Pedretti F, Moles A, Viaplana C, Villacampa G, Guzmán M, Rodríguez O, Grueso J, Jimenez J, Forment JV, O’Connor MJ, Cairo S, Zhou Y, Musolino A, Caldas C, Clarke RB, Nuciforo P, Díez O, Serres X, Peg V, Espinosa M, Macarulla T, Oaknin A, Mateo J, Bellet M, Oliveira M, Saura C, Gutiérrez-Enríquez S, Balmaña J and Serra V (2022) . Cancer Res., 82(8):1646-1657.
Publications 2018:
Ethnicity influences breast cancer stem cells' drug resistance
Kamal, M., Nafie, E. H. O., Elsers, S., Alanwar, S., Ibrahim, R., Farag, F., Mlees, M., Simões, B. M., Spence, K., Santiago-Gómez, A., Salem, M. L. & Clarke, R. B. Jul 2018 In : Breast Journal. 24, 4, p. 701-703 3 p.
Research output: Contribution to journal › Article DOI: 10.1111/tbj.13021 Published
Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP
Piggott, L., Silva, A., Robinson, T., Santiago-Gómez, A., Simões, B. M., Becker, M., Fichtner, I., Andera, L., Young, P., Morris, C., Barrett-Lee, P., Alchami, F., Piva, M., Vivanco, M. DM., Clarke, R. B., Gee, J. & Clarkson, R. 15 May 2018 In : Clinical Cancer Research. 24, 10, p. 2452-2463 12 p.
Research output: Contribution to journal › Article DOI: 10.1158/1078-0432.CCR-17-1381 Published
Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors
M Simoes, B., Kholer, B., Clarke, R., Stringer, J., Novak Frazer, L., Young, K., Richardson, R., Zucchini, G., Armstrong, A. & Howell, S. 2018 In : Therapeutic Advances in Medical Oncology. 10
Research output: Contribution to journal › Article DOI: 10.1177/1758835918766189 Published
GPER mediates the angiocrine actions induced by IGF1 through the HIF-1a/VEGF pathway in the breast tumor microenvironment
De Francesco, E., Sims, A. H., Maggiolini, M., Sotgia, F., Lisanti, M. P. & Clarke, R. 6 Dec 2017 In : Breast Cancer Research. 19, 1, p. 129 14 p.
Research output: Contribution to journal › Article DOI: 10.1186/s13058-017-0923-5 Published
Interrogating open issues in cancer precision medicine with patient-derived xenografts
Byrne, A. T. , Alférez, D. G. , Amant, F. , Annibali, D. , Arribas, J. , Biankin, A. V. , Bruna, A. , Budinská, E. , Caldas, C. , Chang, D. K. , Clarke, R. B. , Clevers, H. , Coukos, G. , Dangles-Marie, V. , Eckhardt, S. G. , Gonzalez-Suarez, E. , Hermans, E. , Hidalgo, M. , Jarzabek, M. A. , de Jong, S. & 22 others 2017 In : Nature reviews. Cancer.
Research output: Contribution to journal › Comment/debate DOI: 10.1038/nrc.2016.140
Leptin as a mediator of tumor-stromal interactions promotes breast cancer stem cell activity.
Giordano, C., Chemi, F., Panza, S., Bonofiglio, D., Lanzino, M., Cordella, A., Campana, A., Hashim, A., Rizza, P., Gyorffy, B., Simões, B. M., Clarke, R., Weisz, A., Catalano, S. & Andò, S.
Oncotarget. 2016. 7, 2, p. 1262-1275 13 p.
An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation
Smit, L., Berns, K., Spence, K., Ryder, W. D., Zeps, N., Madiredjo, M., Beijersbergen, R., Bernards, R. & Clarke, R. B. 19 Jan
Oncotarget. 2016. 7, 3, p. 2596-2610 14 p.
Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells.
Aires, A., Ocampo, S. M., Simões, B. M., Josefa Rodríguez, M., Couleaud, P., Spence, K., Latorre, A., Miranda, R., Somoza, Á., Clarke, R., Carrascosa, J. L. & Cortajarena, A. L.
Nanotechnology. 2016. 27, 6, p. 065103
Cisplatin selects for stem-like cells in osteosarcoma by activating notch signaling
Yu, L., Fan, Z., Fang, S., Yang, J., Gao, T., Simões, B. M., Eyre, R., Guo, W. & Clarke, R. B
Oncotarget. 2016. 7(22): 33055–33068
Intermittent energy restriction induces changes in breast gene expression and systemic metabolism
Harvie, M., Sims, A., Pegington, M., Spence, K., Mitchell, A., Vaughan, A. A., Allwood, W., Xu, Y., Rattray, N., Goodacre, R., Evans, G., Mitchell, E., McMullen, D., Clarke, R. & Howell, A.
Breast Cancer Research. 2016. 18, 1, 57
SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling
Koledova, Z., Zhang, X., Streuli, C., Clarke, R. B., Klein, O. D., Werb, Z. & Lu, P.
PNAS. 2016. 113(39)
Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis
Eyre, R., Alférez, D. G., Spence, K., Kamal, M., Shaw, F. L., Simões, B. M., Santiago-Gómez, A., Sarmiento-Castro, A., Bramley, M., Absar, M., Saad, Z., Chatterjee, S., Kirwan, C., Gandhi, A., Armstrong, A. C., Wardley, A. M., O'Brien, C. S., Farnie, G., Howell, S. J. & Clarke, R. B.
Journal of Mammary Gland Biology and Neoplasia. 2016.
Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.
Simões BM, O'Brien CS, Eyre R, Silva A, Yu L, Sarmiento-Castro A, Alférez DG, Spence K, Santiago-Gómez A, Chemi F, Acar A, Gandhi A, Howell A, Brennan K, Rydén L, Catalano S, Andó S, Gee J, Ucar A, Sims AH, Marangoni E, Farnie G, Landberg G, Howell SJ, Clarke RB.
Cell Rep. 2015 Sep 29;12(12):1968-77. doi: 10.1016/j.celrep.2015.08.050.
Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy.
Williams KE, Bundred NJ, Landberg G, Clarke RB, Farnie G.
Stem Cells. 2015 Feb;33(2):327-41. doi: 10.1002/stem.1843.