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Ashu Gandhi

Mr Ashu Gandhi is a Consultant Surgeon in the Nightingale & Genesis Breast Cancer Prevention Centre and Quality Assurance Surgeon for the North West Breast Screening Quality Assurance team.

Honorary Senior Lecture and Consultant Breast & Endocrine Surgeon (MD FRCS)

Nightingale & Genesis Breast Cancer Centre
University Hospital of South Manchester
Southmoor Road
M23 9LT



I am a Consultant Surgeon in the Nightingale & Genesis Breast Cancer Prevention Centre, a recognised centre of excellence based at the University Hospital of South Manchester. This is one of the largest Breast Units in the UK and also one of the busiest breast screening units, receiving referrals from across Greater Manchester and the North West.

I am Quality Assurance Surgeon for the North West Breast Screening Quality Assurance team which acts to ensure consistent and high standards of care for women undergoing breast screening in the region. I sit on the Audit & Screening Committee for the Association of Breast Surgery. In addition I am a member of the Breast Cancer Family History service at the Nightingale & Genesis Centre and member of the Medical Board of The Genesis Breast Cancer Prevention Charity.

I am also fully trained and accredited in Thyroid and Parathyroid Surgery and I run a busy Endocrine Surgery practice at University Hospital of South Manchester and am a core member of the Greater Manchester & Cheshire Thyroid Cancer Team. I am Secretary for the British Association of Endocrine & Thyroid Surgeons and have contributed on their behalf to the British Thyroid Association treatment guidelines.


Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis

Eyre, R., Alférez, D. G., Spence, K., Kamal, M., Shaw, F. L., Simões, B. M., Santiago-Gómez, A., Sarmiento-Castro, A., Bramley, M., Absar, M., Saad, Z., Chatterjee, S., Kirwan, C., Gandhi, A., Armstrong, A. C., Wardley, A. M., O'Brien, C. S., Farnie, G., Howell, S. J. & Clarke, R. B.

Journal of Mammary Gland Biology and Neoplasia. 2016. [Epub ahead of print]


Increased peri-ductal collagen micro-organization may contribute to raised mammographic density.


McConnell JC, O'Connell OV, Brennan K, Weiping L, Howe M, Joseph L, Knight D, O'Cualain R, Lim Y, Leek A, Waddington R, Rogan J, Astley SM, Gandhi A, Kirwan CC, Sherratt MJ, Streuli CH.

Breast Cancer Res. 2016 Jan 8;18(1):5. doi: 10.1186/s13058-015-0664-2.


Longer term effects of the Angelina Jolie effect: increased risk-reducing mastectomy rates in BRCA carriers and other high-risk women.

Evans DG, Wisely J, Clancy T, Lalloo F, Wilson M, Johnson R, Duncan J, Barr L, Gandhi A, Howell A.

Breast Cancer Res. 2015 Nov 25;17:143. doi: 10.1186/s13058-015-0650-8.


Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.

Simões BM, O'Brien CS, Eyre R, Silva A, Yu L, Sarmiento-Castro A, Alférez DG, Spence K, Santiago-Gómez A, Chemi F, Acar A, Gandhi A, Howell A, Brennan K, Rydén L, Catalano S, Andó S, Gee J, Ucar A, Sims AH, Marangoni E, Farnie G, Landberg G, Howell SJ, Clarke RB.

Cell Rep. 2015 Sep 29;12(12):1968-77. doi: 10.1016/j.celrep.2015.08.050.


Current attitudes to breast reconstruction surgery for women at risk of post-mastectomy radiotherapy: A survey of UK breast surgeons.

Duxbury PJ, Gandhi A, Kirwan CC, Jain Y, Harvey JR.

Breast. 2015 Aug;24(4):502-12. doi: 10.1016/j.breast.2015.05.002.


Ashu Gandhi is collaborating with the Welcome Centre for Cell Matrix Research examining the molecular basis of mammographic density. In addition, he has projects investigating the metabolic effects of chemotherapy on breast cancer patients and examining the surgical outcomes of patients undergoing risk reducing mastectomies. He has published papers on breast reconstruction and is working with colleagues to investigate methods to improve breast reconstruction outcomes.

Optimum duration of neoadjuvant letrozole to permit breast conserving surgery.

Carpenter R, Doughty JC, Cordiner C, Moss N, Gandhi A, Wilson C, Andrews C, Ellis G, Gui G, Skene AI.

Breast Cancer Res Treat. 2014 Apr;144(3):569-76. doi: 10.1007/s10549-014-2835-8.


Use of Pre-Ablation Radioiodine-131 Scan to Assess the Impact of Surgical Volume and Specialisation following Thyroidectomy for Differentiated Thyroid Carcinoma.

Yap BK, Homer J, Parrott N, Loughran S, Murby B, Swindell R, Gandhi A.

Eur Thyroid J. 2013 Dec;2(4):275-81. doi: 10.1159/000355911.


Oncological screening for Bilateral Breast Reduction: a survey of practice variations in UK Breast and Plastics surgeons 2009.

Hennedige AA, Kong TY, Gandhi A.

J Plast Reconstr Aesthet Surg. 2011 Jul;64(7):878-83. doi: 10.1016/j.bjps.2010.12.001.