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Dr Andrew Gilmore

Andrew Gilmore is interested in how adhesion mediated signalling regulates mammary epithelial cell survival.


Michael Smith Building
Oxford Road
M13 9PT

Tel: +44 (0)161 275 3892, +44 (0)161 275 5576


Wellcome Trust Centre for Cell-Matrix Research

Aug. 2010 - Present Senior Lecturer (associate professor equivalent)

Faculty of Life Sciences

University of Manchester

June 2004 - July 2012 Lecturer (assistant professor equivalent)

Faculty of Life Sciences

University of Manchester

July 2000 June 2004 Wellcome Research Career Development Fellow

Faculty of Life Sciences

University of Manchester,

Jan. 1997 - June 2004 Post doctoral research associate

School of Biological Sciences,

University of Manchester

Jan. 1994 - Dec. 1996 EMBO Postdoctoral Fellow

Dept. Cell Biology and Anatomy

University of North Carolina at Chapel Hill


BA (Hons) Zoology 1989 Merton College, Oxford

PhD Biochemistry 1993 University of Leicester

Oncogenic activation of FAK drives apoptosis suppression in a 3D-culture model of breast cancer initiation.

Walker, S., Foster, F., Wood, A., Owens, T., Brennan, K., Streuli, C., & Gilmore, A.

Oncotarget. 2016. [Epub ahead of print]

The Integrin-Mediated ILK-Parvin-aPix Signalling Axis Controls Differentiation in Mammary Epithelial Cells.

Rooney, N., Wang, P., Brennan, K., Gilmore, A., & Streuli, C.

Journal of Cellular Physiology. 2016. 231(11):2408-17/

Mitosis and Mitochondrial Priming for Apoptosis.

Pedley, R., & Gilmore, A.

Biological Chemistry. 2016. 397(7):595-605.

Axl Tyrosine Kinase Protects against Tubulo-Interstitial Apoptosis and Progression of Renal Failure in a Murine Model of Chronic Kidney Disease and Hyperphosphataemia,

G. D. Hyde, R. F. Taylor, N. Ashton, S. J. Borland, H. S. G. Wu, A. P. Gilmore, A. E. Canfield, D. Long, Ed.

PLoS ONE 9, e102096 (2014).

Phosphorylation of the proapoptotic BH3-only protein bid primes mitochondria for apoptosis during mitotic arrest,

P. Wang, J. Lindsay, T. W. Owens, E. J. Mularczyk, S. Warwood, F. Foster, C. H. Streuli, K. Brennan, A. P. Gilmore,

Cell Reports 7, 661–671 (2014).

Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming,

B. Schellenberg, P. Wang, J. A. Keeble, R. Rodriguez-Enriquez, S. Walker, T. W. Owens, F. Foster, J. Tanianis-Hughes, K. Brennan, C. H. Streuli, A. P. Gilmore,

Mol Cell 49, 959–971 (2013).

Bcl-2 proteins and mitochondria--specificity in membrane targeting for death,

J. Lindsay, M. D. Esposti, A. P. Gilmore

Biochim. Biophys. Acta 1813, 532–539 (2011).

Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization,

T. W. Owens, F. M. Foster, A. Valentijn, A. P. Gilmore, C. H. Streuli,

J. Biol. Chem. 285, 1081–1088 (2010).

Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes,

P. D. Arkwright, F. Luchetti, J. Tour, C. Roberts, R. Ayub, A. P. Morales, J. J. Rodríguez, A. Gilmore, B. Canonico, S. Papa, M. D. Esposti,

Cell Res. 20, 72–88 (2010).

Regulation of Cell survival by Cell / Extracellular Matrix Adhesion

My primary research interest is how adhesion mediated signalling regulates mammary epithelial cell survival. Cells require signals from the extracellular matrix (ECM) to provide them with positional information regarding their context within a tissue. Not only is this information required for cells to proliferate and differentiate, but also the absence of positional cues results in apoptosis, a genetically defined programme to remove damaged, displaced or surplus cells. Precise regulation of apoptosis is critical to cell function and its perturbation is seen in many diseases, such as cancer. Apoptosis is controlled by the Bcl-2 family of proteins, which form pores that release a variety of factors from mitochondria (e.g. cytochrome c, Smac/DIABLO) required for initiating cell death. Permeabilisation of the outer mitochondrial membrane is, therefore, the central event in the apoptotic programme and its correct regulation is vital. Bcl-2 proteins respond to a range of different types of cellular stress, resulting in changes in the interactions between them that set a threshold for apoptosis. We have recently found that cells adjust their apoptotic threshold rapidly as their circumstances change, setting themselves up to die when stressed, but then resetting this threshold is survival signals are restored. We are looking at how this threshold changes dynamically over time as cells respond to different internal and external signals. In particular, we are interested in how these changes may affect how cells respond to chemotherapeutic drugs.

P. M. Peixoto, S.-Y. Ryu, D. P. Pruzansky, M. Kuriakose, A. Gilmore, K. W. Kinnally,

Mitochondrial apoptosis is amplified through gap junctions,

Biochem. Biophys. Res. Commun. 390, 38–43 (2009).

A. Manara, J. Lindsay, M. Marchioretto, A. Astegno, A. P. Gilmore, M. D. Esposti, M. Crimi,

Bid binding to negatively charged phospholipids may not be required for its pro-apoptotic activity in vivo,

Biochim. Biophys. Acta 1791, 997–1010 (2009).

A. P. Gilmore, T. W. Owens, F. M. Foster, J. Lindsay,

How adhesion signals reach a mitochondrial conclusion--ECM regulation of apoptosis,

Curr. Opin. Cell Biol. 21, 654–661 (2009).

T. W. Owens, A. J. Valentijn, J.-P. Upton, J. Keeble, L. Zhang, J. Lindsay, N. K. Zouq, A. P. Gilmore,

Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK,

Cell Death Differ 16, 1551–1562 (2009).

O. Meurette, S. Stylianou, R. Rock, G. M. Collu, A. P. Gilmore, K. Brennan,

Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells,

Cancer Res. 69, 5015–5022 (2009).

N. K. Zouq, J. A. Keeble, J. Lindsay, A. J. Valentijn, L. Zhang, D. Mills, C. E. Turner, C. H. Streuli, A. P. Gilmore,

FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas,

J. Cell. Sci. 122, 357–367 (2009).


A. J. Valentijn, J.-P. Upton, N. Bates, A. P. Gilmore,

Bax targeting to mitochondria occurs via both tail anchor-dependent and -independent mechanisms,

Cell Death Differ 15, 1243–1254 (2008).

A. J. Valentijn, J.-P. Upton, A. P. Gilmore,

Analysis of endogenous Bax complexes during apoptosis using blue native PAGE: implications for Bax activation and oligomerization,

Biochem. J. 412, 347–357 (2008).

Collett GD, Sage AP, Kirton JP, Alexander MY, Gilmore AP, Canfield AE, (2007)

Axl/phosphatidylinositol 3-kinase signaling inhibits mineral deposition by vascular smooth muscle cells.

Circulation research 100(4): 502-9.

Upton JP, Valentijn AJ, Zhang L, Gilmore AP, (2007)

The N-terminal conformation of Bax regulates cell commitment to apoptosis.

Cell Death and Differentiation In press: In press.

Valentijn AJ, Gilmore AP (2004)

Translocation of full-length Bid to mitochondria during anoikis.

Journal of Biological Chemistry 279(31): 32848-57.


Valentijn AJ, Zouq N, Gilmore AP (2004)


Biochemical Society transactions 32(Pt3): 421-5.


Wang P, Gilmore AP, Streuli CH (2004)

Bim is an apoptosis sensor that responds to loss of survival signals delivered by epidermal growth factor but not those provided by integrins.

Journal of Biological Chemistry 279(40): 41280-5.


Zoubiane GS, Valentijn A, Lowe ET, Akhtar N, Bagley S, Gilmore AP, Streuli CH (2004)

A role for the cytoskeleton in prolactin-dependent mammary epithelial cell differentiation.

Journal of cell science 117(Pt 2): 271-80.

Lee AV, Schiff R, Cui X, Sachdev D, Yee D, Gilmore AP, Streuli CH, Oesterreich S, Hadsell DL (2003)

New mechanisms of signal transduction inhibitor action: receptor tyrosine kinase down-regulation and blockade of signal transactivation.

Clinical cancer research : an official journal of the American Association for Cancer Research 9(1 Pt 2): 516S-23S.


Ranger AM, Zha J, Harada H, Datta SR, Danial NN, Gilmore AP, Kutok JL, Le Beau MM, Greenberg ME, Korsmeyer SJ (2003)

Bad-deficient mice develop diffuse large B cell lymphoma.

Proceedings of the National Academy of Sciences of the United States of America 100(16): 9324-9.


Valentijn AJ, Metcalfe AD, Kott J, Streuli CH, Gilmore AP (2003)

Spatial and temporal changes in Bax subcellular localization during anoikis.

The Journal of cell biology 162(4): 599-612.


Wang P, Valentijn AJ, Gilmore AP, Streuli CH (2003)

Early events in the anoikis program occur in the absence of caspase activation.

Journal of Biological Chemistry 278(22): 19917-25.

Gilmore AP, Streuli CH (2002)

Analyzing apoptosis in cultured epithelial cells.

Methods in molecular biology (Clifton, N.J.) 188: 145-55.


Gilmore AP, Valentijn AJ, Wang P, Ranger AM, Bundred N, O"Hare MJ, Wakeling A, Korsmeyer SJ, Streuli CH (2002)

Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor.

Journal of Biological Chemistry 277(31): 27643-50.

Hadjiloucas I, Gilmore AP, Bundred NJ, Streuli CH (2001)

Assessment of apoptosis in human breast tissue using an antibody against the active form of caspase 3: relation to tumour histopathological characteristics.

British journal of cancer 85(10): 1522-6.

Gilmore AP, Metcalfe AD, Romer LH, Streuli CH (2000)

Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization.

The Journal of cell biology 149(2): 431-46.