Milestones
Manchester has long played a key role in the development of new approaches for the prevention, diagnosis and treatment of breast cancer. Explore our world-leading discoveries here.
Edith Paterson
1944
Targeted therapies in breast cancer: stil-boestrol and phenylethylene (early tamoxifen like inhibitor)
Ralston Paterson
1948
First randomised trial in cancer: adjuvant ovarian irradiation
Moya Cole and Ian Todd
1969
First clinical use of tamoxifen
Andrew Baildam and Tony Howell
1987
First pre-surgical use of tamoxifen
Charles Streuli
1991
Control of mammary differentiation by extra cellular matrix
Rob Clarke
1997
ER+ cells rarely divide in mammary epithelium
Nigel Bundred
1999
Xeno-transplantation model of human DCIS
Rob Clarke
2005
Identification and regulation of stem cells in human breast epithelium
Keith Brennan
2006
Aberrant activation of Notch in Breast Cancer
Gillian Farnie
2007
Identification of stem cells in ductal carcinoma in situ
Gareth Evans
2007
Identification of novel breast cancer susceptibility genes
Sacha Howell
2008
A role for prolactin in breast cancer stem cells
Andrew Gilmore
2009
Focal Adhesion Kinase (FAK) regulates apoptosis in mammary epithelial cells
Michelle Harvie
2013
The 5:2 (intermittent) diet for breast cancer reduction in high risk women