Doxycycline and therapeutic targeting of the DNA damage response in cancer cells: old drug, new purpose.
Peiris-Pagès M, Sotgia F, Lisanti MP.
Oncoscience. 2015 Aug 24;2(8):696-9. eCollection 2015.
Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT/FGF-driven anabolic signaling.
Lamb R, Bonuccelli G, Ozsvári B, Peiris-Pagès M, Fiorillo M, Smith DL, Bevilacqua G, Mazzanti CM, McDonnell LA, Naccarato AG, Chiu M, Wynne L, Martinez-Outschoorn UE, Sotgia F, Lisanti MP.
Oncotarget. 2015 Sep 28. [Epub ahead of print]
High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant.
Farnie G, Sotgia F, Lisanti MP.
Oncotarget. 2015 Sep 30. [Epub ahead of print]
Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells.
Lamb R, Ozsvari B, Bonuccelli G, Smith DL, Pestell RG, Martinez-Outschoorn UE, Clarke RB, Sotgia F, Lisanti MP.
Oncotarget. 2015 Sep 8;6(26):21892-905.
Estrogen related receptor a (ERRa) a promising target for the therapy of adrenocortical carcinoma (ACC).
Casaburi I, Avena P, De Luca A, Chimento A, Sirianni R, Malivindi R, Rago V, Fiorillo M, Domanico F, Campana C, Cappello AR, Sotgia F, Lisanti MP, Pezzi V.
Oncotarget. 2015 Sep 22;6(28):25135-48. doi: 10.18632/oncotarget.4722.
Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells.
De Luca A, Fiorillo M, Peiris-Pagès M, Ozsvari B, Smith DL, Sanchez-Alvarez R, Martinez-Outschoorn UE, Cappello AR, Pezzi V, Lisanti MP, Sotgia F.
Oncotarget. 2015 Jun 20;6(17):14777-95.
Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy.
Lamb R, Fiorillo M, Chadwick A, Ozsvari B, Reeves KJ, Smith DL, Clarke RB, Howell SJ, Cappello AR, Martinez-Outschoorn UE, Peiris-Pagès M, Sotgia F, Lisanti MP.
Oncotarget. 2015 Jun 10;6(16):14005-25.
Monocytes and macrophages, implications for breast cancer migration and stem cell-like activity and treatment.
Ward R, Sims AH, Lee A, Lo C, Wynne L, Yusuf H, Gregson H, Lisanti MP, Sotgia F, Landberg G, Lamb R.
Oncotarget. 2015 Jun 10;6(16):14687-99.
Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells.
Peiris-Pagès M, Sotgia F, Lisanti MP.
Oncotarget. 2015 May 10;6(13):10728-45.
Caveolae and signalling in cancer.
Martinez-Outschoorn UE, Sotgia F, Lisanti MP.
Nat Rev Cancer. 2015 Apr;15(4):225-37. doi: 10.1038/nrc3915. Review.
Graphene oxide selectively targets cancer stem cells, across multiple tumor types: implications for non-toxic cancer treatment, via "differentiation-based nano-therapy".
Fiorillo M, Verre AF, Iliut M, Peiris-Pagés M, Ozsvari B, Gandara R, Cappello AR, Sotgia F, Vijayaraghavan A, Lisanti MP.
Oncotarget. 2015 Feb 28;6(6):3553-62.
Targeting tumor-initiating cells: eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction.
Lamb R, Harrison H, Smith DL, Townsend PA, Jackson T, Ozsvari B, Martinez-Outschoorn UE, Pestell RG, Howell A, Lisanti MP, Sotgia F.
Oncotarget. 2015 Mar 10;6(7):4585-601.
Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease.
Lamb R, Ozsvari B, Lisanti CL, Tanowitz HB, Howell A, Martinez-Outschoorn UE, Sotgia F, Lisanti MP.
Oncotarget. 2015 Mar 10;6(7):4569-84.
The reverse Warburg effect in osteosarcoma.
Sotgia F, Martinez-Outschoorn UE, Lisanti MP.
Oncotarget. 2014 Sep 30;5(18):7982-3.
Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition.
Lamb R, Harrison H, Hulit J, Smith DL, Lisanti MP, Sotgia F.
Oncotarget. 2014 Nov 30;5(22):11029-37.
Metabolic Asymmetry in Cancer: A “Balancing Act” that Promotes Tumor Growth
UE Martinez-Outschoorn, F Sotgia, MP Lisanti
Cancer cell, 2014
JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention
A Howell, UE Martinez-Outschoorn, F Sotgia
Cell …, 2013 - landesbioscience.com
Evidence for a stromal-epithelial “lactate shuttle” in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts
S Pavlides, R Gandara, RG Pestell, F Sotgia…
Cell …, 2011
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.
Martinez-Outschoorn UE, Balliet RM, Rivadeneira DB, Chiavarina B, Pavlides S, Wang C, Whitaker-Menezes D, Daumer KM, Lin Z, Witkiewicz AK, Flomenberg N, Howell A, Pestell RG, Knudsen ES, Sotgia F, Lisanti MP.
Cell Cycle. 2010 Aug 15;9(16):3256-76. doi: 10.4161/cc.9.16.12553.
Ketones and lactate “fuel” tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
A Howell, UE Martinez-Outschoorn, F Sotgia
Cell cycle, 2010 - ncbi.nlm.nih.gov
Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NF?B activation in the tumor stromal …
A Howell, RG Pestell, J Caro, MP Lisanti, F Sotgia
Cell cycle, 2010 - ncbi.nlm.nih.gov
The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism
…, UE Martinez-Outschoorn, A Howell, F Sotgia
Cell Cycle, 2010 - ncbi.nlm.nih.gov
An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers
AK Witkiewicz, A Dasgupta, F Sotgia, I Mercier
The American journal of …, 2009 - Elsevier